EVISTA® (Raloxifene HCl 60mg.)

In March 1999, Eli Lilly and Company released a new product called EVISTA for prevention of osteoporosis in postmenopausal women.  EVISTA decreases your risk for future fracture and is indicated for the treatment of osteoporosis.  Widely accepted risk factors for osteoporosis include Caucasian or Asian decent, slender body build, early estrogen deficiency such as premature menopause, or hysterectomy and removal of the ovaries before the age of 50, smoking, alcohol consumption, low calcium diet, sedentary lifestyle, and family history. Supplemental calcium and vitamin D need to be added if the dietary intake is inadequate

EVISTA is not a traditional estrogen hormone - it is a selective estrogen receptor modulator (SERM).  EVISTA activates specific estrogen receptors while it does not activate others, such as those in breast tissue.  EVISTA has estrogen effects in bone and on lipid metabolism to decrease the total cholesterol and LDL (the bad cholesterol), and it lacks estrogen-like activity on breast and uterine tissue.

Therefore, EVISTA :

  • Preserves bone
  • Reduces the risk of spinal fracture
  • Is proven to reduce the risk of invasive breast cancer in postmenopausal women with Osteoporosis  
  • Does not cause breast tenderness or vaginal bleeding
  • Does not increase the risk of breast or endometrial cancer in studies thus performed up to 30 months
  • Lowers total cholesterol and LDL but does not increase HDL or triglyceride levels.

There is no need for progesterone supplementation - a 60mg. tablet once a day, anytime, with or without food, is fine.

Adverse effects of this medication include: a rare, but serious, side effect which is venous thromboembolism (deep vein clot).  The greatest risk occurs during the first four months of treatment.  Other drug related side effects are hot flashes in 24.6% vs. placebo 18.3% and leg cramps in 5.9% vs. placebo 1.9%.  The safety of this drug in patients with severe liver insufficiency is not known.  The use of EVISTA with estrogen or progestin has not been studied and is not recommended.

Regular exercise is another way to build strong bones and prevent heart disease. 

More information is available regarding calcium in "Meeting your calcium needs".








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