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OVERVIEW OF NON-HORMONAL AGENTS FOR HOT FLASHES



Agent
 


Classification
 


Dose
 


Mechanism of Action
 


Side Effects
 
Vitamin E*

 

Vitamin

 

800 IU daily

 

Prevents excessive PHS and LH production

 

None at this dose

 

Vitamin C plus bioflavinoids (Peridin C)*

 

Bioflavinoid

 

2 tablets three times daily

 

Enhances capillary tone

 

Perspiration may have an unpleasant odor

 

Clonidine (Catapres)

 

a-adrenergic agonist

 

0.05 mg twice daily (may increase to 0.1  mg twice daily if hot flashes persist)

 

Reduces vascular reactivity, stabilizes thermoregulatory center

 

Hypotension, dizziness, and fatigue

 

Clonidine Transdermal Patches (Catapres-TTS)

 

a-adrenergic agonis

 

0.1 mg patches, change weekly

 

Reduces vascular reactivity, stabilizes thermoregulatory center

 

Hypotension, dizziness, and fatigue

 

Phenobarbital-belladonna-ergot amine combination (Bellergal-S)

 

Autonomic stabilizer

 

One at bedtime, if ineffective, one twice daily

 

Inhibits adrenergic and cholinergic impulses locally

 

Dry mouth, dizziness, drowsiness, addictive potential

 

 

Venlafaxine (Effexor)

 

 

Antidepressant

 

12.5 gm twice daily

 

Inhibits neuronal serotonin and norepinerphine re-uptake, SSRI and NERI

 

Anxiety, nervousness, insomnia (minimal at this dose) potential interaction with MAO inhibitors

 

Paroxetine (Paxil)

 

Antidepressant

 

10 mg daily for 1 week, then 20 mg daily

 

Selectively inhibits re-uptake of serotonin SSRI

 

Somnolence

 

  • See also Hormone Therapy, Menopause, or Lupron Therapy for ways to cope with menopausal symptoms.
  • Other treatments such as exercise and deep breathing will help.
  • Please see the "Cool Menopause" AM and PM and PMS/Perimenopause Supplements available on our website.

* Available over the counter





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